Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Prognostic value of neutrophil-to-lymphocyte ratio in stroke: a systematic review and meta-analysis

W Li, M Hou, Z Ding, X Liu, Y Shao, X Li - Frontiers in Neurology, 2021 - frontiersin.org
Background: Stroke has become a major problem around the world, which is one of the
main causes of long-term disability. Therefore, it is important to seek a biomarker to predict …

Anti-inflammatory targets for the treatment of reperfusion injury in stroke

A Mizuma, MA Yenari - Frontiers in neurology, 2017 - frontiersin.org
While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Neutrophil-to-lymphocyte ratio is a prognostic marker in acute ischemic stroke

J Xue, W Huang, X Chen, Q Li, Z Cai, T Yu… - Journal of Stroke and …, 2017 - Elsevier
Background Neutrophil-to-lymphocyte ratio is an independent predictor of mortality in
patients with acute ischemic stroke. However, it is uncertain whether neutrophil-to …

Targeting neutrophils in ischemic stroke: translational insights from experimental studies

GC Jickling, DZ Liu, BP Ander… - Journal of Cerebral …, 2015 - journals.sagepub.com
Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

[HTML][HTML] Stroke statistics in Korea: part I. Epidemiology and risk factors: a report from the korean stroke society and clinical research center for stroke

KS Hong, OY Bang, DW Kang, KH Yu, HJ Bae… - Journal of …, 2013 - ncbi.nlm.nih.gov
The aim of the Part I of Stroke Statistics in Korea is to summarize nationally representative
data of the epidemiology and risk factors of stroke in a single document. Every year …

Neutrophil lymphocyte ratio as a predictor of stroke

S Tokgoz, M Kayrak, Z Akpinar, A Seyithanoğlu… - Journal of Stroke and …, 2013 - Elsevier
Background The aim of this study is to investigate the relationship of the neutrophil to
lymphocyte ratio (NLR) with short-term mortality in acute stroke. Methods This retrospective …

Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes

I Maestrini, D Strbian, S Gautier, E Haapaniemi… - Neurology, 2015 - AAN Enterprises
Objective: To determine whether higher neutrophil counts before IV recombinant tissue
plasminogen activator (rtPA) administration in ischemic stroke (IS) patients are associated …

Update on inflammatory biomarkers and treatments in ischemic stroke

A Bonaventura, L Liberale, A Vecchié… - International journal of …, 2016 - mdpi.com
After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …

Systemic inflammation as a therapeutic target in acute ischemic stroke

T Dziedzic - Expert review of neurotherapeutics, 2015 - Taylor & Francis
Acute systemic inflammatory reaction superimposed on chronic low-grade inflammation
accompanies acute ischemic stroke. Elevated blood levels of systemic inflammatory markers …