Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development

GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates

JL Goodson, AH Bass - Brain research reviews, 2001 - Elsevier
The neuropeptide arginine vasotocin (AVT; non-mammals) and its mammalian homologue,
arginine vasopressin (AVP) influence a variety of sex-typical and species-specific behaviors …

Modulation of social memory in male rats by neurohypophyseal peptides

R Dantzer, RM Bluthe, GF Koob, M Le Moal - Psychopharmacology, 1987 - Springer
Adult male rats spend a great amount of time investigating novel juveniles. In contrast, rats
re-exposed to the same juvenile 30 min after the initial exposure display little investigatory …

Circumventricular organs: definition and role in the regulation of endocrine and autonomic function

WF Ganong - Clinical and Experimental Pharmacology and …, 2000 - Wiley Online Library
The circumventricular organs (CVO) are structures that permit polypeptide hypothalamic
hormones to leave the brain without disrupting the blood–brain barrier (BBB) and permit …

Behavioral consequences of intracerebral vasopressin and oxytocin: focus on learning and memory

M Engelmann, CT WOTJAK, I Neumann… - Neuroscience & …, 1996 - Elsevier
ENGELMANN, M., CT WOTJAK, I. NEUMANN, M. LUDWIG AND R. LANDGRAF. Behavioral
consequences of intracerebral vasopressin and oxytocin: Focus on learning and memory …

The central vasopressinergic system: examining the opportunities for psychiatric drug development

RH Ring - Current pharmaceutical design, 2005 - ingentaconnect.com
Arginine vasopressin (AVP) is a cyclic nonapeptide synthesized exclusively by
neurosecretory cells of the central nervous system (CNS). Two functionally distinct …

Centrally injected arginine vasopressin (AVP) facilitates social memory in rats

M Le Moal, R Dantzer, B Michaud, GF Koob - Neuroscience letters, 1987 - Elsevier
Abstract 'Memory'for a juvenile conspecific in male rats can be measured by variation in
duration of investigation times when the same juvenile is presented at different intervals …

Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol‐dependent rats

S Edwards, M Guerrero, OM Ghoneim… - Addiction …, 2012 - Wiley Online Library
Alcoholism is a devastating condition that represents a progression from initial alcohol use
to dependence. Although most individuals are capable of consuming alcohol in a limited …

Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats

BC Nephew, RS Bridges - Pharmacology Biochemistry and Behavior, 2008 - Elsevier
Maternal aggression is a robust type of aggression displayed by lactating female rats.
Although arginine vasopressin (AVP) has been implicated in the control of male aggression …

The effects of separate or combined infusions of corticotrophin-releasing factor and vasopressin either intraventricularly or into the amygdala on aggressive and …

DR Elkabir, ME Wyatt, SV Vellucci, J Herbert - Regulatory peptides, 1990 - Elsevier
These experiments show that combined infusions of corticotrophin-releasing factor (CRF)
and arginine vasopressin (AVP) into either the lateral ventricle or the amygdalae have …