The secret ally: immunostimulation by anticancer drugs
It has recently become clear that the tumour microenvironment, and in particular the immune
system, has a crucial role in modulating tumour progression and response to therapy …
system, has a crucial role in modulating tumour progression and response to therapy …
[HTML][HTML] Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape
The quest for treatment-free remission (TFR) and deep molecular response (DMR) in
chronic myeloid leukemia (CML) has been profoundly impacted by tyrosine kinase inhibitors …
chronic myeloid leukemia (CML) has been profoundly impacted by tyrosine kinase inhibitors …
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
INTRODUCTION More than 50% of patients treated with chimeric antigen receptor (CAR)–T
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
Reversible ON-and OFF-switch chimeric antigen receptors controlled by lenalidomide
Cell-based therapies are emerging as effective agents against cancer and other diseases.
As autonomous “living drugs,” these therapies lack precise control. Chimeric antigen …
As autonomous “living drugs,” these therapies lack precise control. Chimeric antigen …
Effective combinatorial immunotherapy for castration-resistant prostate cancer
X Lu, JW Horner, E Paul, X Shang, P Troncoso, P Deng… - Nature, 2017 - nature.com
A significant fraction of patients with advanced prostate cancer treated with androgen
deprivation therapy experience relapse with relentless progression to lethal metastatic …
deprivation therapy experience relapse with relentless progression to lethal metastatic …
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis.
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …
Broad-spectrum kinase profiling in live cells with lysine-targeted sulfonyl fluoride probes
Protein kinases comprise a large family of structurally related enzymes. A major goal in
kinase-inhibitor development is to selectively engage the desired kinase while avoiding …
kinase-inhibitor development is to selectively engage the desired kinase while avoiding …
Infusion of donor-derived CD19-redirected virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase 1 study
Autologous T cells expressing a CD19-specific chimeric antigen receptor (CD19. CAR) are
active against B-cell malignancies, but it is unknown whether allogeneic CD19. CAR T cells …
active against B-cell malignancies, but it is unknown whether allogeneic CD19. CAR T cells …
Pharmacologic control of CAR-T cell function using dasatinib
Chimeric antigen receptor (CAR) T-cell therapy mediates high response rates in
relapsed/refractory B-cell malignancies. 1, 2, 3, 4 However, some patients experience …
relapsed/refractory B-cell malignancies. 1, 2, 3, 4 However, some patients experience …
[HTML][HTML] Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
M Ilander, U Olsson-Strömberg, H Schlums, J Guilhot… - Leukemia, 2017 - nature.com
Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in
deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment …
deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment …