We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …

An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …

Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …

Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Abstract Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …

Alzheimer's disease is characterized by abnormal elevation of Aβ peptide and abnormal
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …

The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …

Mitochondrial dysfunction is a hallmark of amyloid‐beta (Aβ)‐induced neuronal toxicity in
Alzheimer′ s disease (AD). The recent emphasis on the intracellular biology of Aβ and its …

Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …