Alzheimer's disease risk genes and mechanisms of disease pathogenesis
We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …
AD pathogenesis. More recent advances in understanding of the human genome …
Alzheimer's disease
An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …
Alzheimer's disease genetics: from the bench to the clinic
Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong - Annual review of neuroscience, 2011 - annualreviews.org
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
A Salminen, K Kaarniranta, A Kauppinen, J Ojala… - Progress in …, 2013 - Elsevier
The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …
The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
S Mishra, A Knupp, MP Szabo, CA Williams… - Cellular and Molecular …, 2022 - Springer
Abstract Background Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …
causal event for Alzheimer's disease (AD). Recent studies have established that loss of …
Linking Aβ and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
Alzheimer's disease is characterized by abnormal elevation of Aβ peptide and abnormal
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …
hyperphosphorylation of the tau protein. The" amyloid hypothesis," which is based on …
The Alzheimer's disease β-secretase enzyme, BACE1
SL Cole, R Vassar - Molecular neurodegeneration, 2007 - Springer
The pathogenesis of Alzheimer's disease is highly complex. While several pathologies
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …
characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark …
Amyloid‐Beta interaction with mitochondria
L Pagani, A Eckert - International Journal of Alzheimer's …, 2011 - Wiley Online Library
Mitochondrial dysfunction is a hallmark of amyloid‐beta (Aβ)‐induced neuronal toxicity in
Alzheimer′ s disease (AD). The recent emphasis on the intracellular biology of Aβ and its …
Alzheimer′ s disease (AD). The recent emphasis on the intracellular biology of Aβ and its …
The genetics and neuropathology of Alzheimer's disease
GD Schellenberg, TJ Montine - Acta neuropathologica, 2012 - Springer
Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …