Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
The roles of Polycomb repressive complexes in mammalian development and cancer
A Piunti, A Shilatifard - Nature reviews Molecular cell biology, 2021 - nature.com
More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …
[HTML][HTML] The long and short non-coding RNAs modulating EZH2 signaling in cancer
S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …
encoding proteins. However, they participate in developmental and biological processes …
EZH2-targeted therapies in cancer: hype or a reality
ML Eich, M Athar, JE Ferguson III, S Varambally - Cancer research, 2020 - AACR
Next-generation genomic sequencing has identified multiple novel molecular alterations in
cancer. Since the identification of DNA methylation and histone modification, it has become …
cancer. Since the identification of DNA methylation and histone modification, it has become …
Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
[HTML][HTML] Chromatin organization in early land plants reveals an ancestral association between H3K27me3, transposons, and constitutive heterochromatin
Genome packaging by nucleosomes is a hallmark of eukaryotes. Histones and the pathways
that deposit, remove, and read histone modifications are deeply conserved. Yet, we lack …
that deposit, remove, and read histone modifications are deeply conserved. Yet, we lack …
Polycomb gene silencing mechanisms: PRC2 chromatin targeting, H3K27me3'readout', and phase separation-based compaction
Modulation of chromatin structure and/or modification by Polycomb repressive complexes
(PRCs) provides an important means to partition the genome into functionally distinct …
(PRCs) provides an important means to partition the genome into functionally distinct …
[HTML][HTML] Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …
[HTML][HTML] 3D chromatin architecture and transcription regulation in cancer
Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …
[HTML][HTML] PRC2. 1-and PRC2. 2-specific accessory proteins drive recruitment of different forms of canonical PRC1
Summary Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …
thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to …