Snake venoms in drug discovery: Valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

[HTML][HTML] Why do we study animal toxins?

Y Zhang - Zoological research, 2015 - ncbi.nlm.nih.gov
Venom (toxins) is an important trait evolved along the evolutionary tree of animals. Our
knowledges on venoms, such as their origins and loss, the biological relevance and the …

[PDF][PDF] Innovative approaches to neutralizing cobra venom: Advances in antivenomics and recombinant antivenoms

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

Varespladib (LY315920) appears to be a potent, broad-spectrum, inhibitor of snake venom phospholipase A2 and a possible pre-referral treatment for envenomation

M Lewin, S Samuel, J Merkel, P Bickler - Toxins, 2016 - mdpi.com
Snakebite remains a neglected medical problem of the developing world with up to 125,000
deaths each year despite more than a century of calls to improve snakebite prevention and …

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients bitten by …

MR Lewin, RW Carter, IA Matteo, SP Samuel, S Rao… - Toxins, 2022 - mdpi.com
The availability of effective, reliably accessible, and affordable treatments for snakebite
envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin …

Long-term effects of snake envenoming

S Waiddyanatha, A Silva, S Siribaddana, GK Isbister - Toxins, 2019 - mdpi.com
Long-term effects of envenoming compromise the quality of life of the survivors of snakebite.
We searched MEDLINE (from 1946) and EMBASE (from 1947) until October 2018 for clinical …

What are the neurotoxins in hemotoxic snake venoms?

A Osipov, Y Utkin - International journal of molecular sciences, 2023 - mdpi.com
Snake venoms as tools for hunting are primarily aimed at the most vital systems of the prey,
especially the nervous and circulatory systems. In general, snakes of the Elapidae family …

Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across …

M Damm, M Karış, D Petras… - Journal of proteome …, 2024 - ACS Publications
Snake venom variations are a crucial factor to understand the consequences of snakebite
envenoming worldwide, and therefore it is important to know about toxin composition …

Snake venom: from deadly toxins to life-saving therapeutics

H Waheed, SF Moin… - Current medicinal …, 2017 - ingentaconnect.com
Snakes are fascinating creatures and have been residents of this planet well before ancient
humans dwelled the earth. Venomous snakes have been a figure of fear, and cause notable …