Treatment of Benzodiazepine Dependence | New England Journal of Medicine Skip to main
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This paper reviews studies examining the pharmacological interactions and epidemiology of
the combined use of opioids and benzodiazepines (BZDs). A search of English language …

Benzodiazepine (BZD) abuse has reached epidemic levels and results in poor outcomes,
particularly when combined with concomitant central nervous system depressants. BZDs are …

Background Use of sedatives may increase risk of death in opioid users. The aim of the
study was to assess whether prescription of sedatives may be associated with mortality in …

Methadone is used for the treatment of opioid addiction and for treatment of chronic pain.
The safety of methadone has been called into question by data indicating a large increase in …

The first hypnotic barbiturate, barbital, was introduced into clinical practice in 1903, followed
by phenobarbital in 1912. 1 In subsequent years, multiple barbiturates were synthesized …

ABSTRACT Background and Aims Benzodiazepines are commonly prescribed to patients
with opioid use disorder receiving buprenorphine treatment, yet may increase overdose risk …

Abstract Objective Benzodiazepines (BZDs) are commonly used by chronic pain patients,
despite limited evidence of any long-term benefits and concerns regarding adverse events …

Objective An expert panel convened to reach a consensus on common misconceptions
surrounding buprenorphine, a Schedule III partial µ-opioid receptor agonist indicated for …

Background Polydrug abuse is a known problem among opioid-dependent patients
receiving opioid maintenance treatment (OMT). However, improved laboratory diagnostics is …