Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

[HTML][HTML] The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

Y Yang, W Yujiao, W Fang, Y Linhui, G Ziqi… - Biological …, 2020 - SciELO Chile
Osteoporosis is a common metabolic bone disease, influenced by genetic and
environmental factors, that increases bone fragility and fracture risk and, therefore, has a …

Rational design of multifunctional CuS nanoparticle‐PEG composite soft hydrogel‐coated 3D hard polycaprolactone scaffolds for efficient bone regeneration

X Xue, H Zhang, H Liu, S Wang, J Li… - Advanced Functional …, 2022 - Wiley Online Library
Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for
application in bone tissue engineering. However, PCL‐based scaffolds with enhanced …

[HTML][HTML] Exosome-guided bone targeted delivery of Antagomir-188 as an anabolic therapy for bone loss

Y Hu, X Li, Q Zhang, Z Gu, Y Luo, J Guo, X Wang… - Bioactive materials, 2021 - Elsevier
The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal
stem cells (BMSCs) characterizes many pathological bone loss conditions. Stromal cell …

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Q Chen, P Shou, C Zheng, M Jiang, G Cao… - Cell Death & …, 2016 - nature.com
Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Osteoblast differentiation and signaling: established concepts and emerging topics

M Ponzetti, N Rucci - International Journal of Molecular Sciences, 2021 - mdpi.com
Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

L Han, B Wang, R Wang, S Gong, G Chen… - Stem cell research & …, 2019 - Springer
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into several
tissues, such as bone, cartilage, and fat. Glucocorticoids affect a variety of biological …

[HTML][HTML] Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine

A González-González, D García-Sánchez… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are the most frequently used stem cells in clinical trials due
to their easy isolation from various adult tissues, their ability of homing to injury sites and …

Adaptable hydrogels mediate cofactor‐assisted activation of biomarker‐responsive drug delivery via positive feedback for enhanced tissue regeneration

K Zhang, Z Jia, B Yang, Q Feng, X Xu… - Advanced …, 2018 - Wiley Online Library
The targeted and simultaneous delivery of diverse cargoes with vastly different properties by
the same vehicle is highly appealing but challenging. Here, a bioactive nanocomposite …

[HTML][HTML] Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway

XJ Chen, YS Shen, MC He, F Yang, P Yang… - Biomedicine & …, 2019 - Elsevier
Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory disease induced
by glucocorticoids. Marrow mesenchymal stem cells (MSCs) differentiate into multiple bone …