Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …

Sarcopenic obesity: definition, cause and consequences : Current Opinion in Clinical Nutrition &
Metabolic Care Sarcopenic obesity: definition, cause and consequences : Current Opinion in …

The recommended daily allowance (RDA) for protein, as promulgated by the Food and
Nutrition Board of the United States National Academy of Science, is 0.8 g protein/kg body …

Growth hormone (GH) is a key determinant of postnatal growth and plays an important role
in the control of metabolism and body composition. Surprisingly, deficiency in GH signaling …

Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …

Sarcopenia and frailty are both highly relevant entities with regard to functionality and
independence in the elderly. The term sarcopenia has been introduced already in the late …

Background: Sarcopenia is increasingly being recognized as a feature of frailty in old age
and is associated with unfavorable health outcomes in Western populations. Little is known …

Sarcopenia is a geriatric condition that comprises declined skeletal muscle mass, strength
and function, leading to the risk of multiple adverse outcomes, including death. Its …

Preclinical evidence that targeting the insulin-like growth factor receptor (IGF-IR) is effective
in cancer treatment has been accumulating for almost two decades. Efforts to develop drugs …

Background: Exposure to some perfluoroalkyl substances (PFAS), such as perfluorohexane
sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and …