Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

Many complex diseases have historically proven to be defiant to the best mono-therapeutic
approaches. Several examples of combination therapies have largely overcome such …

Both type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD) strongly associate
with increasing body mass index, and together these metabolic diseases affect millions of …

Obesity is one of the major challenges to human health worldwide; however, there are
currently no effective pharmacological interventions for obesity. Recent studies have …

Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism
and promotes weight loss, as reflected by the wasting observed in glucagonoma patients …

We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and
glucagon-like peptide 1 receptor (GLP-1R)–deficient mice after the administration of the …

Aims To investigate, for a given energy expenditure (EE) rise, the differential effects of
glucagon infusion and cold exposure on brown adipose tissue (BAT) activation in humans …

Gastrointestinal hormones and regulation of gastric emptying : Current Opinion in Endocrinology,
Diabetes and Obesity Gastrointestinal hormones and regulation of gastric emptying : Current …

Adaptive thermogenesis (AT) with weight loss refers to underfeeding‐associated fall in
resting and non‐resting energy expenditure (REE, non‐REE); this is independent of body …

Context Cotadutide is a dual receptor agonist with balanced glucagon-like peptide-1 and
glucagon activity. Objective To evaluate different doses of cotadutide and investigate …