Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair
Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of
bulky lesions from DNA and is characterized by an extraordinarily wide substrate specificity …
bulky lesions from DNA and is characterized by an extraordinarily wide substrate specificity …
Repair-resistant DNA lesions
NE Geacintov, S Broyde - Chemical research in toxicology, 2017 - ACS Publications
The eukaryotic global genomic nucleotide excision repair (GG-NER) pathway is the major
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
mechanism that removes most bulky and some nonbulky lesions from cellular DNA. There is …
Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex
Failure in repairing ultraviolet radiation-induced DNA damage can lead to mutations and
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …
cancer. Among UV-lesions, the pyrimidine–pyrimidone (6-4) photoproduct (6-4PP) is …
Single-molecule imaging reveals that Rad4 employs a dynamic DNA damage recognition process
Nucleotide excision repair (NER) is an evolutionarily conserved mechanism that processes
helix-destabilizing and/or-distorting DNA lesions, such as UV-induced photoproducts. Here …
helix-destabilizing and/or-distorting DNA lesions, such as UV-induced photoproducts. Here …
Mechanism and regulation of DNA damage recognition in mammalian nucleotide excision repair
K Sugasawa - The Enzymes, 2019 - Elsevier
Nucleotide excision repair (NER) is a versatile DNA repair pathway that eliminates various
helix-distorting base lesions such as ultraviolet (UV)-induced photolesions. Several …
helix-distorting base lesions such as ultraviolet (UV)-induced photolesions. Several …
[HTML][HTML] The moonlighting of RAD23 in DNA repair and protein degradation
M Grønbæk-Thygesen, C Kampmeyer… - … et Biophysica Acta (BBA …, 2023 - Elsevier
A moonlighting protein is one, which carries out multiple, often wholly unrelated, functions.
The RAD23 protein is a fascinating example of this, where the same polypeptide and the …
The RAD23 protein is a fascinating example of this, where the same polypeptide and the …
Nucleotide Excision Repair Lesion-Recognition Protein Rad4 Captures a Pre-Flipped Partner Base in a Benzo[a]pyrene-Derived DNA Lesion: How Structure Impacts …
The xeroderma pigmentosum C protein complex (XPC) recognizes a variety of
environmentally induced DNA lesions and is the key in initiating their repair by the …
environmentally induced DNA lesions and is the key in initiating their repair by the …
Mapping the recognition pathway of cyclobutane pyrimidine dimer in DNA by Rad4/XPC
UV radiation-induced DNA damages have adverse effects on genome integrity and cellular
function. The most prevalent UV-induced DNA lesion is the cyclobutane pyrimidine dimer …
function. The most prevalent UV-induced DNA lesion is the cyclobutane pyrimidine dimer …
Rad4 recognition-at-a-distance: Physical basis of conformation-specific anomalous diffusion of DNA repair proteins
M Kong, B Van Houten - Progress in biophysics and molecular biology, 2017 - Elsevier
Abstract Since Robert Brown's first observations of random walks by pollen particles
suspended in solution, the concept of diffusion has been subject to countless theoretical and …
suspended in solution, the concept of diffusion has been subject to countless theoretical and …
Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide …
Rad4/XPC recognizes diverse DNA lesions including ultraviolet-photolesions and
carcinogen-DNA adducts, initiating nucleotide excision repair. Studies have suggested that …
carcinogen-DNA adducts, initiating nucleotide excision repair. Studies have suggested that …