Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Sirtuins are stress‐responsive proteins that direct various post‐translational modifications
(PTM s) and as a result, are considered to be master regulators of several cellular …

Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human
cancers, where they display both oncogenic and tumor-suppressive properties depending …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Backgrounds The role of sphere-forming culture in enriching subpopulations with stem-cell
properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its …

Altering energy metabolism to meet the uncontrolled proliferation and metastasis has
emerged as one of the most significant hallmarks in tumors. However, the detailed molecular …

Parkinson's disease is characterized by progressive death of dopaminergic neurons,
leading to motor and cognitive dysfunction. Epidemiological studies consistently show that …

Abstract Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin
family, which plays a key role in cancer by controlling transcription, genome stability …

Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of
current therapeutic regimens to fully eradicate disease-initiating leukemia stem cells (LSC) …