[HTML][HTML] Cervical cancer in low and middle‑income countries

R Hull, M Mbele, T Makhafola, C Hicks… - Oncology …, 2020 - spandidos-publications.com
Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two
histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more …

Context-dependent functions of pattern recognition receptors in cancer

SM Man, BJ Jenkins - Nature Reviews Cancer, 2022 - nature.com
The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Implications of Toll-like receptors (TLRs) and their signaling mechanisms in human cancers

SA Chandrasekar, T Palaniyandi… - … -Research and Practice, 2023 - Elsevier
Most essential pattern-recognition receptors regulating innate immune functions are toll-like
receptors (TLRs). TLRs are characterized by lack of concurrent epithelial markers and are …

The toll-like receptor 4 polymorphism Asp299Gly is associated with an increased risk of ovarian cancer

KD Kania, D Haręża, JR Wilczyński, M Wilczyński… - Cells, 2022 - mdpi.com
Ovarian cancer (OC) is one of the most common cancers threatening women's lives around
the world. Epithelial ovarian tumors represent the most common ovarian neoplasms. Most …

The role of Toll-like receptor 4 signaling pathway in ovarian, cervical, and endometrial cancers

LA Lupi, MS Cucielo, HS Silveira, LB Gaiotte… - Life sciences, 2020 - Elsevier
Toll-like receptors (TLRs) are critical sensors related to inflammation and tumorigenesis.
Among all subtypes, the TLR4 is a highly described transmembrane protein involved in the …

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

M Preti, S Rosso, L Micheletti, C Libero, I Sobrato… - BMC cancer, 2020 - Springer
Background The aim was to estimate the risk of subsequent extra-cervical Human
Papillomavirus (HPV) related cancer in patients surgically treated for high grade cervical …

Polymorphisms and haplotypes of TLR-4/9 associated with bacterial infection, gingival inflammation/recession and oral cancer

A Jha, N Nath, A Kumari, N Kumari, AK Panda… - … -Research and Practice, 2023 - Elsevier
Abstract Background The expression and SNPs of innate immunity genes TLR-4/9 for
bacterial infection, gingival inflammation/gingival recession (GIGR), and oral squamous cell …

Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis

N Pandey, A Chauhan, N Raithatha, P Patel… - Microbial …, 2021 - Elsevier
Genetic polymorphism in pathogen recognition receptors tends to influence infection,
disease susceptibility, and progression. We analyzed the association of TLR4 and TLR9 …

Role of toll-like receptor in the pathogenesis of oral cancer

A Bhardwaj, D Prasad, S Mukherjee - Cell Biochemistry and Biophysics, 2024 - Springer
Toll-like receptors are important molecules of innate immunity. They are known as pattern
recognition receptors. They recognise certain molecules known as pathogen-associated …

Toll-like receptor 4–a multifunctional virus recognition receptor

E Gerber-Tichet, FP Blanchet, K Majzoub… - Trends in Microbiology, 2024 - cell.com
Since the initial description of Toll receptors in Drosophila and their mammalian
counterparts Toll-like receptors (TLRs), numerous fundamental and applied studies have …