Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …

The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess,
Cushing syndrome, create a significant health burden. We found that tissue regeneration of …

In the last decade significant progress has been made in the understanding of
mineralocorticoid receptor (MR) function and its implications for physiology and disease …

We have previously shown that hexarelin, a novel GH-releasing peptide (GHRP), is able to
elicit GH release when administered iv, sc or by mouth and that it is a more potent GH …

Glucocorticoid (GC) excess adversely affects skin integrity, inducing thinning and impaired
wound healing. Aged skin, particularly that which has been photo-exposed, shares a similar …

Objectives The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a well-
characterised role in the metabolism and activation of endogenous glucocorticoids (GCs) …

Abstract Congenital vertebral malformation, affecting 0.13–0.50 per 1000 live births, has an
immense locus heterogeneity and complex genetic architecture. In this study, we analyze …

Brown adipocytes display phenotypic plasticity, as they can switch between the active states
of fatty acid oxidation and energy dissipation versus a more dormant state. Cold exposure or …

Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management
of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions …