Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

In the past three decades, a great interest has arisen in the use of immunoglobulins as
therapeutic agents. In particular, since the approval of the first monoclonal antibody …

Numerous monoclonal antibodies have been developed successfully for the treatment of
various diseases. Nevertheless, the development of biotherapeutic antibodies is complex …

ABSTRACT A key question in immunology is whether antigen recognition and Fc receptor
(FcR) binding are allosterically linked. This question is also relevant for therapeutic antibody …

B cells are known to contribute to the anti-tumor immune response, especially in
immunogenic tumors such as melanoma, yet humoral immunity has not been characterized …

We hypothesize that different routes of administration may lead to altered pharmacokinetics/
pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to …

Therapeutic antibodies have shifted the paradigm of disease treatments from small
molecules to biologics, especially in cancer therapy. Despite the increasing number of …

It has been well-established that antibody isotype, glycosylation, and epitope all play roles in
the process of antibody dependent cellular cytotoxicity (ADCC). For natural killer (NK) cells …

Among all approaches in molecular imaging, the combination of near-infrared fluorescence
imaging (NIRF) with radioisotopic imaging (PET or SPECT) allows one to benefit from the …

In the last few decades, antibody-based diagnostic and therapeutic applications have been
well established in medicine and have revolutionized cancer managements by improving …