Up to 30% of people with schizophrenia do not respond to two (or more) trials of
dopaminergic antipsychotics. They are said to have treatment-resistant schizophrenia (TRS) …

Abstract Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only
metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also …

Language evolution resulted from changes in our biology, behavior, and culture. One source
of these changes might be human self-domestication. Williams syndrome (WS) is a clinical …

Clozapine is an efficacious atypical antipsychotic for treatment-refractory schizophrenia.
Clinical response and appearance of adverse events vary among individual patients …

Introduction Clozapine (CLZ) is the gold standard drug for treatment-refractory
schizophrenia (TRS). However, approximately 30% of patients partially respond to CLZ …

Background Type 2 diabetes mellitus (T2DM), one of the global health issues, is a group of
metabolic diseases and is affected by several genetic loci in the clinical phenotype. This …

This aim of the study was to investigate the effect of CYP1A2 gene polymorphism on the
metabolism of theophylline in minority and Han nationality. A total of 50 cases of Han (Han …

The aim of this thesis is to investigate treatment response and the adverse effects of
clozapine, a uniquely effective antipsychotic medication in the management of …

Clozapine (CLZ) has been an antipsychotic of choice in treatment refractory schizophrenia
(TRS). However, around 30% of the patients do not respond appropriately to this …

La esquizofrenia es un trastorno psiquiátrico grave e incapacitante, caracterizado por un
conjunto de desórdenes mentales que incluyen alucinaciones, alteraciones en el afecto, en …