Hemolysis, long discounted as a critical measure of sickle cell disease severity when
compared with sickle vaso-occlusion, may be the proximate cause of some disease …

The asymmetric phospholipid distribution in plasma membranes is normally maintained by
energy-dependent lipid transporters that translocate different phospholipids from one …

Despite recent advances in understanding the pathophysiologic mechanisms behind the
thalassemia intermedia (TI) phenotype, data on the effects of treatment are deficient. To …

Traditional concepts of the pathogenesis of chronic thromboembolic pulmonary
hypertension (CTEPH) invoke a thromboembolic origin. However, neither classic plasmatic …

Thalassemia intermedia encompasses a wide clinical spectrum of beta-thalassemia
phenotypes. Some thalassemia intermedia patients are asymptomatic until adult life …

Thalassemia is a growing global public health problem with an estimated 900,000 births of
clinically significant thalassemia disorders expected to occur in the next 20 years. This …

Our understanding of the molecular and pathophysiological mechanisms underlying the
disease process in patients with β thalassaemia intermedia (TI) has substantially increased …

New developments in the epidemiology, treatment and prognosis of thalassemia have
dramatically altered the approach to the care of affected patients, and these developments …

As the defective genes for more and more genetic disorders become unravelled, it is clear
that patients with apparently identical genotypes can have many different clinical conditions …

Background: An increased prevalence of splenectomy has been reported in patients with
idiopathic pulmonary arterial hypertension. Examination of small pulmonary arteries from …