Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies
N Gupta, S Shyamasundar, R Patnala… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Chronic activation of microglia is the hallmark of numerous neuropathologies
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The activated …
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The activated …
Colony stimulating factors in the nervous system
V Chitu, F Biundo, ER Stanley - Seminars in immunology, 2021 - Elsevier
Although traditionally seen as regulators of hematopoiesis, colony-stimulating factors (CSFs)
have emerged as important players in the nervous system, both in health and disease. This …
have emerged as important players in the nervous system, both in health and disease. This …
Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease
RL Jayaraj, S Azimullah, KA Parekh, SK Ojha… - Heliyon, 2022 - cell.com
Citronellol, a monoterpene found in the essential oils of Cymbopogo plants has been
reported to possess various biological properties. In the present study, we investigated the …
reported to possess various biological properties. In the present study, we investigated the …
Roflumilast escalates α-synuclein aggregate degradation in rotenone-induced Parkinson's disease in rats: Modulation of the ubiquitin-proteasome system and …
Perturbation of the protein homeostasis circuit is one of the principal attributes associated
with many neurodegenerative disorders, such as Parkinson's disease (PD). This study …
with many neurodegenerative disorders, such as Parkinson's disease (PD). This study …
Neuroprotection through G-CSF: recent advances and future viewpoints
Granulocyte-colony stimulating factor (G-CSF), a member of the cytokine family of
hematopoietic growth factors, is 19.6 kDa glycoprotein which is responsible for the …
hematopoietic growth factors, is 19.6 kDa glycoprotein which is responsible for the …
Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down …
Oxidative stress and neuroinflammation play key roles in the initiation and progression of
Parkinson's disease (PD), a neurodegenerative disorder, associated with the loss of …
Parkinson's disease (PD), a neurodegenerative disorder, associated with the loss of …
The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats
Most treatments for Parkinson's disease (PD) focus on improving the symptoms and the
dopaminergic effects; nevertheless, they cannot delay the disease progression. Diosmin …
dopaminergic effects; nevertheless, they cannot delay the disease progression. Diosmin …
The effects of gallic acid and vagotomy on motor function, intestinal transit, brain electrophysiology and oxidative stress alterations in a rat model of Parkinson's …
Abstract Introduction The neuropathology of Parkinson's disease (PD) is complex and affects
multiple systems of the body beyond the central nervous system. This study examined the …
multiple systems of the body beyond the central nervous system. This study examined the …
Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: possible role of endocannabinoid system …
AY Labib, RM Ammar, RN El-Naga, AAZ El-Bahy… - International …, 2021 - Elsevier
Parkinson's disease (PD) is a disabling progressive neurodegenerative disease. So far,
PD's treatment remains symptomatic with no curative effects. Aside from its blatant analgesic …
PD's treatment remains symptomatic with no curative effects. Aside from its blatant analgesic …
The role of KATP channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson's disease
NF Abdelkader, HA Farid, ER Youness… - Life Sciences, 2020 - Elsevier
Aims Several studies suggested that ATP-sensitive potassium channels (K ATP) are
potential therapeutic targets for protection against various neurodegenerative disorders, yet …
potential therapeutic targets for protection against various neurodegenerative disorders, yet …