Periodontitis is a common chronic inflammatory disease characterised by destruction of the
supporting structures of the teeth (the periodontal ligament and alveolar bone). It is highly …

Collagen cross-linking, a major post-translational modification of collagen, plays important
roles in the biological and biomechanical features of bone. Collagen cross-links can be …

Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β
peptides, and the family of β-sheet fibrils have been shown to contribute to a number of …

Objective: This report reviews the evidence for adverse effects of diabetes on periodontal
health and periodontal disease on glycemic control and complications of diabetes. Design …

Advanced glycation end products (AGEs), a group of compounds that are formed by non-
enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of …

Data have accumulated to show that various types of collagen crosslinking are implicated in
the health of individuals, as well as in a number of disease states, such as osteoporosis …

The impact of AGEs on human MSCs was studied. AGEs inhibited the proliferation of MSCs,
induced apoptosis, and prevented cognate differentiation into adipose tissue, cartilage, and …

For many years an association between diabetes and periodontitis has been suspected. In
more recent times this relationship has been suggested to be bidirectional with each …

Diabetes, particularly type 2 diabetes, is a looming health issue with many ramifications.
Because diabetes alters the cellular microenvironment in many different types of tissues, it …

Although melatonin has a variety of biological actions such as antitumor, antiangiogenic,
and antioxidant activities, the osteogenic mechanism of melatonin still remains unclear …