The fractal dimension of chromatin-a potential molecular marker for carcinogenesis, tumor progression and prognosis
K Metze, R Adam, JB Florindo - Expert review of molecular …, 2019 - Taylor & Francis
Introduction: Fractality is omnipresent in medicine and life sciences. In particular, the fractal
principle is found simultaneously at different organization levels of the cell nucleus. The aim …
principle is found simultaneously at different organization levels of the cell nucleus. The aim …
Stochastic motion and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome
Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …
functional processes, including transcription initiation, the pairwise motion of distal …
[HTML][HTML] Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis
EM Hildebrand, K Polovnikov, B Dekker, Y Liu… - Molecular cell, 2024 - cell.com
The topological state of chromosomes determines their mechanical properties, dynamics,
and function. Recent work indicated that interphase chromosomes are largely free of …
and function. Recent work indicated that interphase chromosomes are largely free of …
Interphase human chromosome exhibits out of equilibrium glassy dynamics
Fingerprints of the three-dimensional organization of genomes have emerged using
advances in Hi-C and imaging techniques. However, genome dynamics is poorly …
advances in Hi-C and imaging techniques. However, genome dynamics is poorly …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus
The large-scale organization of the genome inside the cell nucleus is critical for the cell's
function. Chromatin—the functional form of DNA in cells—serves as a template for active …
function. Chromatin—the functional form of DNA in cells—serves as a template for active …
Chromatin compaction multiscale modeling: a complex synergy between theory, simulation, and experiment
Understanding the mechanisms that trigger chromatin compaction, its patterns, and the
factors they depend on, is a fundamental and still open question in Biology. Chromatin …
factors they depend on, is a fundamental and still open question in Biology. Chromatin …
Dynamic nucleosome movement provides structural information of topological chromatin domains in living human cells
The mammalian genome is organized into submegabase-sized chromatin domains (CDs)
including topologically associating domains, which have been identified using chromosome …
including topologically associating domains, which have been identified using chromosome …
How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes
The 3D organization of chromosomes is crucial for regulating gene expression and cell
function. Many experimental and polymer modeling efforts are dedicated to deciphering the …
function. Many experimental and polymer modeling efforts are dedicated to deciphering the …
Crumpled polymer with loops recapitulates key features of chromosome organization
Chromosomes are exceedingly long topologically constrained polymers compacted in a cell
nucleus. We recently suggested that chromosomes are organized into loops by an active …
nucleus. We recently suggested that chromosomes are organized into loops by an active …