Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism

CP D'Incal, KE Van Rossem, K De Man, A Konings… - Clinical …, 2023 - Springer
Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

Rho signaling in synaptic plasticity, memory, and brain disorders

H Zhang, Y Ben Zablah, H Zhang, Z Jia - Frontiers in cell and …, 2021 - frontiersin.org
Memory impairments are associated with many brain disorders such as autism, Alzheimer's
disease, and depression. Forming memories involves modifications of synaptic transmission …

Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations

Y Hussein, U Tripathi, A Choudhary, R Nayak… - Translational …, 2023 - nature.com
Abstract Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-
motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of …

Neurons: the interplay between cytoskeleton, ion channels/transporters and mitochondria

P Alberti, S Semperboni, G Cavaletti, A Scuteri - Cells, 2022 - mdpi.com
Neurons are permanent cells whose key feature is information transmission via chemical
and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain …

EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons

SS Parker, KT Ly, AD Grant, J Sweetland… - Journal of Cell …, 2023 - rupress.org
Dendritic spines are the postsynaptic compartment of a neuronal synapse and are critical for
synaptic connectivity and plasticity. A developmental precursor to dendritic spines, dendritic …

Changes in the number and morphology of dendritic spines in the hippocampus and prefrontal cortex of the C58/J mouse model of autism

I Barón-Mendoza, E Maqueda-Martínez… - Frontiers in Cellular …, 2021 - frontiersin.org
Autism spectrum disorder (ASD) has a broad range of neurobiological characteristics,
including alterations in dendritic spines, where approximately 90% of excitatory synapses …

[HTML][HTML] PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model

J Rakotomamonjy, L Rylaarsdam, L Fares-Taie… - Cell reports, 2023 - cell.com
Protocadherins (PCDHs) are cell adhesion molecules that regulate many essential
neurodevelopmental processes related to neuronal maturation, dendritic arbor formation …

The hidden side of NCAM family: NCAM2, a key cytoskeleton organization molecule regulating multiple neural functions

A Parcerisas, A Ortega-Gascó, L Pujadas… - International Journal of …, 2021 - mdpi.com
Although it has been over 20 years since Neural Cell Adhesion Molecule 2 (NCAM2) was
identified as the second member of the NCAM family with a high expression in the nervous …

Mechanical roles of F-actin in the differentiation of stem cells: a review

YL Fan, HC Zhao, B Li, ZL Zhao… - ACS biomaterials science …, 2019 - ACS Publications
In the development and differentiation of stem cells, mechanical forces associated with
filamentous actin (F-actin) play a crucial role. The present review aims to reveal the …

Different functional connectivity optimal frequency in autism compared with healthy controls and the relationship with social communication deficits: evidence from …

J Long, F Lu, S Yang, Q Zhang, X Chen… - Human Brain …, 2023 - Wiley Online Library
Studies have reported that different brain regions/connections possess distinct frequency
properties, which are related to brain function. Previous studies have proposed altered brain …