In vivo deposition of poorly soluble drugs
Z Lou, C Mu, CD Corpstein, T Li - Advanced Drug Delivery Reviews, 2024 - Elsevier
Administered drug molecules, whether dissolved or solubilized, have the potential to
precipitate and accumulate as solid forms in tissues and cells within the body. This phase …
precipitate and accumulate as solid forms in tissues and cells within the body. This phase …
[HTML][HTML] Therapeutic efficiency of Tamoxifen/Orlistat nanocrystals against solid ehrlich carcinoma via targeting TXNIP/HIF1-α/MMP-9/P27 and BAX/Bcl2/P53 signaling …
TA El-Masry, MMF El-Nagar, GA Oriquat… - Biomedicine & …, 2024 - Elsevier
Abstract Background Orlistat (Orli) is an anti-obesity medication that has been approved by
the US Food and Drug Administration. It has relatively limited oral bioavailability with …
the US Food and Drug Administration. It has relatively limited oral bioavailability with …
[HTML][HTML] Anticancer Effect of Cycas media: Molecular Basis Through Modulation of PI3K/AKT/mTOR Signaling Pathway
J Alqahtani, EM Mosalam, HE Abo Mansour, AI Elberri… - Molecules, 2024 - mdpi.com
Many researchers are focusing on screening the biological activities of plants owing to their
safety and possible pharmacological actions. Consequently, we aimed to explore the …
safety and possible pharmacological actions. Consequently, we aimed to explore the …
Dioon rzedowskii: An antioxidant, antibacterial and anticancer plant extract with multi-faceted effects on cell growth and molecular signaling
This study investigated the antioxidant, anticancer, antibacterial properties of Dioon
rzedowskii extract, which had not been previously explored. We aimed to determine the …
rzedowskii extract, which had not been previously explored. We aimed to determine the …
[HTML][HTML] Potential Protective Effect of Orlistat: A Formulation of Nanocrystals Targeting Inflammation, Oxidative Stress, and Apoptosis in an Experimental Model of …
M Alsunbul, TA El-Masry, EI El Zahaby, MMS Gaballa… - Pharmaceutics, 2024 - mdpi.com
Background: Doxorubicin (DOX) is a widely used chemotherapeutic agent; nevertheless,
cardiotoxicity limits its effectiveness. Orlistat (Orli) is an irreversible lipase enzyme inhibitor …
cardiotoxicity limits its effectiveness. Orlistat (Orli) is an irreversible lipase enzyme inhibitor …