The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and
ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to …

The paradigm of cancer-targeted therapies has focused largely on inhibition of critical
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …

Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like
antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective …

Fusobacterium nucleatum, a Gram‐negative oral anaerobe, is a significant contributor to
colorectal cancer. Using an in vitro cancer progression model, we discover that F. nucleatum …