Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism

P Kovacic, R Somanathan - Journal of Applied Toxicology, 2014 - Wiley Online Library
Vehicle pollution is an increasing problem in the industrial world. Aromatic nitro compounds
comprise a significant portion of the threat. In this review, the class includes nitro derivatives …

Environmental occurrence, toxicity concerns, and remediation of recalcitrant nitroaromatic compounds

M Bilal, AR Bagheri, P Bhatt, S Chen - Journal of Environmental …, 2021 - Elsevier
Nitroaromatic compounds (NACs) are considered important groups of chemicals mainly
produced by human and industrial activities. The large-scale application of these …

Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis

Z Zhu, S Du, Y Du, J Ren, G Ying… - Journal of …, 2018 - Wiley Online Library
Glutathione (GSH) and GSH‐related enzymes constitute the most important defense system
that protects cells from free radical, radiotherapy, and chemotherapy attacks. In this study …

An update on derivatisation and repurposing of clinical nitrofuran drugs

NH Zuma, J Aucamp, DND David - European Journal of Pharmaceutical …, 2019 - Elsevier
nitrofurans (NFs) have been in clinical use for over 60 years. These affordable drugs are
used for the treatment of a broad spectrum of diseases ranging from urinary tract infections …

Azoreductases in drug metabolism

A Ryan - British Journal of Pharmacology, 2017 - Wiley Online Library
Azoreductases are flavoenzymes that have been characterized in a range of prokaryotes
and eukaryotes. Bacterial azoreductases are associated with the activation of two classes of …

Salicylic acid derivatives: synthesis, features and usage as therapeutic tools

D Ekinci, M Şentürk, Öİ Küfrevioğlu - Expert opinion on therapeutic …, 2011 - Taylor & Francis
Introduction: In the field of medicinal chemistry, there is a growing interest in the use of small
molecules. Although acetyl salicylic acid is well known for medical applications, little is …

Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives

S Işık, D Vullo, S Durdagi, D Ekinci, M Şentürk… - Bioorganic & Medicinal …, 2015 - Elsevier
A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl,
and allyl moieties were prepared and tested as possible inhibitors of three members of the …

A study on the effects of inhibition mechanism of curcumin, quercetin, and resveratrol on human glutathione reductase through in vitro and in silico approaches

P Güller, M Karaman, U Güller, M Aksoy… - Journal of …, 2021 - Taylor & Francis
Glutathione reductase (GR) is a major antioxidant enzyme essential to maintain GSH/GSSG
ratio by catalyzing recovery of reduced glutathione (GSH) from oxidized glutathione (GSSG) …

Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives

I Fidan, RE Salmas, M Arslan, M Şentürk… - Bioorganic & Medicinal …, 2015 - Elsevier
The inhibition of two human cytosolic carbonic anhydrase isozymes I and II, with some novel
glycine and phenylalanine sulfonamide derivatives were investigated. Newly synthesized …

Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds

D Ekinci, NI Kurbanoglu, E Salamcı… - Journal of enzyme …, 2012 - Taylor & Francis
Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as anti-glaucoma
agents, diuretics and anti-epileptics. We report here the inhibitory capacities of …