Toll‐like receptors: general molecular and structural biology
P Behzadi, HA García-Perdomo… - Journal of Immunology …, 2021 - Wiley Online Library
Background/Aim. Toll‐like receptors (TLRs) are pivotal biomolecules in the immune system.
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …
Distinct and orchestrated functions of RNA sensors in innate immunity
Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
Small-molecule modulators of toll-like receptors
Conspectus Toll-like receptors (TLRs) are the “gatekeepers” of the immune system in
humans and other animals to protect the host from invading bacteria, viruses, and other …
humans and other animals to protect the host from invading bacteria, viruses, and other …
The chaperone UNC93B1 regulates Toll-like receptor stability independently of endosomal TLR transport
Summary Unc-93 homolog B1 (UNC93B1) is a key regulator of nucleic acid (NA)-sensing
Toll-like receptors (TLRs). Loss of NA-sensing TLR responses in UNC93B1-deficient …
Toll-like receptors (TLRs). Loss of NA-sensing TLR responses in UNC93B1-deficient …
Extracellular RNA sensing by pattern recognition receptors
RNA works as a genome and messenger in RNA viruses, and it sends messages in most of
the creatures of the Earth, including viruses, bacteria, fungi, plants, and animals. The human …
the creatures of the Earth, including viruses, bacteria, fungi, plants, and animals. The human …
Anti-TLR7 antibody protects against lupus nephritis in NZBWF1 mice by targeting B cells and patrolling monocytes
Y Murakami, R Fukui, R Tanaka, Y Motoi… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by
autoantibody production and multiple organ damage. Toll-like receptor 7 (TLR7), an innate …
autoantibody production and multiple organ damage. Toll-like receptor 7 (TLR7), an innate …
Mechanisms controlling nucleic acid-sensing Toll-like receptors
Nucleic acid (NA)-sensing Toll-like receptors (TLRs) respond to DNA/RNA derived from
pathogens and dead cells. Structural studies have revealed a variety of molecular …
pathogens and dead cells. Structural studies have revealed a variety of molecular …
Structural analysis reveals TLR7 dynamics underlying antagonism
S Tojo, Z Zhang, H Matsui, M Tahara, M Ikeguchi… - Nature …, 2020 - nature.com
Abstract Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and
nucleosides. Aberrant activation of TLR7 has been implicated in several autoimmune …
nucleosides. Aberrant activation of TLR7 has been implicated in several autoimmune …
TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …
Current understanding of the innate control of toll-like receptors in response to SARS-CoV-2 infection
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It …
respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It …