High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

Dysregulation of the flow of information from genomic DNA to RNA to protein occurs within
all cancer types. In this review, we described the current state of understanding of how RNA …

Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene
expression. AS misregulation, caused by either dysregulation or mutation of splicing factors …

Splicing is a critical processing step during pre-mRNA maturation in eukaryotes. The correct
selection of splice sites during the early steps of spliceosome assembly is highly important …

RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly
dynamic process orchestrated by the spliceosome, a macro-molecular machinery that …

The ability of a cell to properly express its genes depends on optimal transcription and
splicing. RNA polymerase II (RNAPII) transcribes protein-coding genes and produces pre …

RNA splicing is the enzymatic process by which non-protein coding sequences are removed
from RNA to produce mature protein-coding mRNA. Splicing is thereby a major mediator of …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …

Dysregulated pre-mRNA splicing is an emerging Achilles heel of cancers and
myelodysplasias. To expand the currently limited portfolio of small-molecule drug leads, we …

In recent years, RNA has gained traction both as a therapeutic molecule and as a
therapeutic target in several human pathologies. In this review, we consider the approach of …