The mechanism and role of ADAMTS protein family in osteoarthritis

T Li, J Peng, Q Li, Y Shu, P Zhu, L Hao - Biomolecules, 2022 - mdpi.com
Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …

Hitting the Target! Challenges and Opportunities for TGF-β Inhibition for the Treatment of Cardiac fibrosis

M Vistnes - Pharmaceuticals, 2024 - mdpi.com
Developing effective anti-fibrotic therapies for heart diseases holds the potential to address
unmet needs in several cardiac conditions, including heart failure with preserved ejection …

Transcriptomic profiling of mare endometrium at different stages of endometrosis

A Szóstek-Mioduchowska, A Wójtowicz, A Sadowska… - Scientific Reports, 2023 - nature.com
In the current study, transcriptome profiles of mare endometrium, classified into categories I,
IIA, and IIB according to Kenney and Doig, were compared using RNA sequencing …

Revisiting the Role of NAG across the Continuum of Kidney Disease

R Novak, G Salai, S Hrkac, IK Vojtusek, L Grgurevic - Bioengineering, 2023 - mdpi.com
Acute and chronic kidney diseases are an evolving continuum for which reliable biomarkers
of early disease are lacking. The potential use of glycosidases, enzymes involved in …

The progression of obstructive renal fibrosis in rats is regulated by ADAMTS18 gene methylation in the embryonic kidney through the AKT/Notch pathway

B Xu, J Zhang, L Ye, C Yuan - Journal of Biochemical and …, 2024 - Wiley Online Library
This study aimed to explore the mechanism by which postembryonic renal ADAMTS18
methylation influences obstructive renal fibrosis in rats. After exposure to transforming …

Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression?

L Grgurevic, R Novak, G Salai, S Hrkac, M Mocibob… - Biomedicines, 2022 - mdpi.com
Chronic kidney disease (CKD) is the progressive loss of renal function. Although advances
have been made in understanding the progression of CKD, key molecular events in complex …

ADAMTS‐4 as a possible distinguishing indicator between osteoarthritis and haemophilic arthropathy

N Kalebota, G Salai, P Peric, S Hrkac, R Novak… - …, 2022 - Wiley Online Library
Introduction Osteoarthritis (OA) and haemophilic arthropathy (HA) are clinically similar, but
pathologically distinct conditions which result in joint pain and loss of function …

Entwicklung und Evaluierung von spezifischen, peptidbasierten Sonden für die molekulare MRT-Bildgebung von Herz-Kreislauf-Erkrankungen

JO Kaufmann - 2023 - edoc.hu-berlin.de
Die Diagnostik von Kardiovaskulären Erkrankungen erfolgt vorwiegend mit unspezifischen
Methoden, die keine molekularen Informationen über das Gefäß liefern. Die molekulare …

[PDF][PDF] Stage II of Chronic Kidney Disease—A Tipping Point in Disease Progression? Biomedicines 2022, 10, 1522

L Grgurevic, R Novak, G Salai, S Hrkac, M Mocibob… - 2022 - researchgate.net
Chronic kidney disease (CKD) is the progressive loss of renal function. Although advances
have been made in understanding the progression of CKD, key molecular events in complex …

Protein ADAMTS-4 kao mogući biološki biljeg kronične bubrežne bolesti

I Kovačević Vojtušek - 2023 - repozitorij.unizg.hr
Sažetak Provedeno je istraživanje pojavnosti ADAMTS-4 proteina u KBB u cilju utvrđivanja
ove molekule kao novog biološkog biljega KBB. Uključeno je 150 ispitanika podijeljenih u 9 …