Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

Since the discovery of long-term potentiation (LTP) in 1973, thousands of papers have been
published on this intriguing phenomenon, which provides a compelling cellular model for …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

This brief review summarizes 60 years of conceptual advances that have demonstrated a
role for active changes in neuronal connectivity as a controller of behavior and behavioral …

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for
long periods, making it a probable mechanism for memory storage. LTP induction results in …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …