Human vitreous in proliferative diabetic retinopathy: characterization and translational implications
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …
age population. DR is a progressive eye disease caused by long-term accumulation of …
Vitreous and vision degrading myodesopsia
J Sebag - Progress in Retinal and Eye Research, 2020 - Elsevier
Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state,
transparency, and physiologic function (s) within the eye. Myopia and aging alter collagen …
transparency, and physiologic function (s) within the eye. Myopia and aging alter collagen …
Simultaneous improvement in the precision, accuracy, and robustness of label-free proteome quantification by optimizing data manipulation chains*[S]
The label-free proteome quantification (LFQ) is multistep workflow collectively defined by
quantification tools and subsequent data manipulation methods that has been extensively …
quantification tools and subsequent data manipulation methods that has been extensively …
Vitreous antioxidants, degeneration, and vitreo-retinopathy: exploring the links
The transparent vitreous body, which occupies about 80% of the eye's volume, is laden with
numerous enzymatic and non-enzymatic antioxidants that could protect the eye from …
numerous enzymatic and non-enzymatic antioxidants that could protect the eye from …
Diffusion and protein corona formation of lipid-based nanoparticles in the vitreous humor: profiling and pharmacokinetic considerations
The vitreous humor is the first barrier encountered by intravitreally injected nanoparticles.
Lipid-based nanoparticles in the vitreous are studied by evaluating their diffusion with single …
Lipid-based nanoparticles in the vitreous are studied by evaluating their diffusion with single …
The human eye proteome project: updates on an emerging proteome
The human eye is a complex organ consisting of multiple compartments with unique and
specialized properties that reflect their varied functions. Although there have been …
specialized properties that reflect their varied functions. Although there have been …
Proteomic analysis of the bovine and human ciliary zonule
A De Maria, PA Wilmarth, LL David… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: The zonule of Zinn (ciliary zonule) is a system of fibers that centers the crystalline
lens on the optical axis of the eye. Mutations in zonule components underlie syndromic …
lens on the optical axis of the eye. Mutations in zonule components underlie syndromic …
[HTML][HTML] System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
A Alli-Shaik, B Qiu, SL Lai, N Cheung, G Tan… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing
significant vision loss. DR is a multifactorial disease involving changes in retinal …
significant vision loss. DR is a multifactorial disease involving changes in retinal …
Hyalocyte functions and immunology
Introduction Vitreous hyalocyte functions have only recently been explored in-depth. These
macrophage-like cells play critical roles in immunologic surveillance and physiology of the …
macrophage-like cells play critical roles in immunologic surveillance and physiology of the …
Age-related increase of let-7 family microRNA in rat retina and vitreous
PS Akamine, CR Lima, GJ Lustoza-Costa… - Experimental Eye …, 2021 - Elsevier
Vitreous alterations occur from early stages and continue through the normal aging, with
gradual lamellae formation and the appearance of liquefied spaces, which eventually leads …
gradual lamellae formation and the appearance of liquefied spaces, which eventually leads …