Galectin-3 as a next-generation biomarker for detecting early stage of various diseases

A Hara, M Niwa, K Noguchi, T Kanayama, A Niwa… - Biomolecules, 2020 - mdpi.com
Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological
activities in various organs, including cell proliferation, apoptotic regulation, inflammation …

Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

SH Nielsen, AJ Mouton, KY DeLeon-Pennell… - Matrix Biology, 2019 - Elsevier
Cardiovascular Disease (CVD) is the most common cause of death in industrialized
countries, and myocardial infarction (MI) is a major CVD with significant morbidity and …

[HTML][HTML] Acute myocardial infarction and myocardial ischemia-reperfusion injury: a comparison

S Hashmi, S Al-Salam - International journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Myocardial infarction (MI) denotes the death of cardiac myocytes due to extended ischemia.
Myocardial reperfusion is the restoration of coronary blood flow after a period of coronary …

[HTML][HTML] Myocardial ischemia reperfusion injury: apoptotic, inflammatory and oxidative stress role of galectin-3

S Al-Salam, S Hashmi - Cellular Physiology and Biochemistry, 2018 - karger.com
Background/Aims: Myocardial reperfusion has the potential to salvage the ischemic
myocardium after a period of coronary occlusion. Reperfusion, however, can cause a wide …

Inhibition of galectin-3 pathway prevents isoproterenol-induced left ventricular dysfunction and fibrosis in mice

G Vergaro, M Prud'Homme, L Fazal, R Merval… - …, 2016 - Am Heart Assoc
Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling.
Previous evidence shows that Gal-3 interacts with aldosterone in promoting macrophage …

The interplay of galectins-1,-3, and-9 in the immune-inflammatory response underlying cardiovascular and metabolic disease

AA Mansour, F Krautter, Z Zhi, AJ Iqbal… - Cardiovascular …, 2022 - Springer
Galectins are β-galactoside-binding proteins that bind and crosslink molecules via their
sugar moieties, forming signaling and adhesion networks involved in cellular …

Galectin-3 in acute coronary syndrome

L Agnello, G Bivona, BL Sasso, C Scazzone… - Clinical …, 2017 - Elsevier
Acute coronary syndrome (ACS) is a very common cause of hospitalizations worldwide each
year. In the past decades biomarkers have become an indispensable tool for diagnosis, risk …

Galectin-3: a potential prognostic and diagnostic marker for heart disease and detection of early stage pathology

A Hara, M Niwa, T Kanayama, K Noguchi, A Niwa… - Biomolecules, 2020 - mdpi.com
The use of molecular biomarkers for the early detection of heart disease, before their onset
of symptoms, is an attractive novel approach. Ideal molecular biomarkers, those that are …

The utility of growth differentiation factor-15, galectin-3, and sST2 as biomarkers for the diagnosis of heart failure with preserved ejection fraction and compared to …

SW Rabkin, JKK Tang - Heart failure reviews, 2021 - Springer
The objective was to evaluate the diagnosis of heart failure with preserved ejection fraction
(HFpEF) using the biomarkers, growth differentiation factor-15 (GDF-15), galectin-3 (Gal-3) …

Galectin-3 and post-myocardial infarction cardiac remodeling

WC Meijers, AR van der Velde… - European journal of …, 2015 - Elsevier
This review summarizes the current literature regarding the involvement and the putative
role (s) of galectin-3 in post-myocardial infarction cardiac remodeling. Post-myocardial …