Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

Scavenger receptors were originally identified by their ability to recognize and to remove
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have
significant cardiovascular morbidity and mortality that is in part due to the development of …

Systemic inflammation in end-stage renal disease is an established risk factor for mortality
and a catalyst for other complications, which are related to a premature aging phenotype …

Calcium phosphate is applied in many products in biomedicine, but also in toothpastes and
cosmetics. In some cases, it is present in nanoparticulate form, either on purpose or after …

Background and aims Vascular calcification is prevalent in clinical states characterized by
low-grade chronic inflammation, such as chronic kidney disease (CKD). Calciprotein …

The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …

Medial arterial calcification is accelerated in patients with CKD and strongly associated with
increased arterial rigidity and cardiovascular mortality. Recently, a novel in vitro blood test …

Obesity, the epidemic of the 21st century, carries a markedly increased risk for comorbid
complications, such as type 2 diabetes, cancer, hypertension, dyslipidemia, cardiovascular …

Objective—Inhibition of mineral crystal formation is a crucial step in ectopic calcification.
Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) …