The human and simian immunodeficiency viruses (HIV and SIV) downregulate the cell
surface expression of CD4. their primary receptor, and of class I histocompatibility complex …

Phenotypic effects of Nef expression in cell culture 2.1. Downregulation of CD4 and MHC I
molecules 2.2. Nef increases the infectivity of virus particles 2.3. Nef affects host cell signal …

ABSTRACT A number of recent studies have demonstrated the significance of detergent-
insoluble, glycolipid-enriched membrane domains or lipid rafts, especially in regard to …

Gene expression profiling was used to explore the role of Nef in HIV. Nef induces a
transcriptional program in T cells that is 97% identical to that of anti-CD3 T cell activation …

The Nef protein is an important virulence factor of primate lentiviruses, yet the mechanisms
by which it exerts this influence are imperfectly understood. Here, using an inducible system …

Background: Human immunodeficiency virus (HIV) Nef protein accelerates virulent
progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific …

CD4 is the primary receptor for the human immunodeficiency virus (HIV). Nef is an
accessory protein of HIV that decreases the expression of CD4 on the surface of infected …

HIV-1-infected lymphocytes improperly respond to T cell antigen receptor (TCR) stimulation.
To document this phenomenon, we studied the capacity of HIV-1-infected lymphocytes to …

The ability of HIV-1 to establish an infection and replicate to high copy number in CD4
lymphocytes is dependent on both the activation state of the cell and virus-encoded …

The nef gene product of human immunodeficiency virus type 1 (HIV-1) is important for the
induction of AIDS, and key to its function is its ability to manipulate T-cell function by …