Genome sequencing provides a wealth of information on predicted gene products (mostly
proteins), but the majority of these have no known function. Two-dimensional gel …

Structural analyses of the large and small ribosomal subunits have allowed us to think about
how they work in more detail than ever before. The mechanisms that underlie ribosomal …

Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and
its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and …

The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates
against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby …

We describe the crystal structure of the complete Thermus thermophilus 70 S ribosome
containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

We have used the recently determined atomic structure of the 30S ribosomal subunit to
determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and …

Crystal structures of the 30 S ribosomal subunit in complex with messenger RNA and
cognate transfer RNA in the A site, both in the presence and absence of the antibiotic …

The ribosome is a macromolecular assembly that is responsible for protein biosynthesis
following genetic instructions in all organisms. It is composed of two unequal subunits: the …

During the ribosomal translocation, the binding of elongation factor G (EF-G) to the
pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the …