Seasonality patterns are reported in various psychiatric disorders. The current paper
summarizes findings on brain adaptations associated with seasonal changes, factors that …

Chronic stress accounts for billions of dollars of economic loss annually in the United States
alone, and is recognized as a major source of disability and mortality worldwide. Robust …

Context The monoamine theory of depression proposes that monoamine levels are lowered,
but there is no explanation for how monoamine loss occurs. Monoamine oxidase A (MAO-A) …

Daily variations in the environment have shaped life on Earth, with circadian cycles
identified in most living organisms. Likewise, seasons correspond to annual environmental …

Light exerts powerful biological effects on mood regulation. Whereas the source of photic
information affecting mood is well established at least via intrinsically photosensitive retinal …

In depression, symptoms range from loss of motivation and energy to suicidal thoughts.
Moreover, in depression alterations might be also observed in the sleep-wake cycle and in …

Objective: In adults with attention-deficit/hyperactivity disorder (ADHD), a delayed
sleep/activity rhythm and/or seasonal mood symptoms may contribute significantly to core …

This review summarizes research on the chronobiology and neurobiology of winter
seasonal affective disorder (SAD), a recurrent subtype of depression characterized by a …

Substantia nigra (SN) hyperechogenicity is a characteristic transcranial sonography (TCS)
finding in idiopathic Parkinson's disease. SN hyperechogenicity, found also in∼ 10% of …

The serendipitous discovery of the precursors of two of the major contemporary
antidepressant families during the late 1950s, iproniazid for the monoamine oxidase …