Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and
metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic …

Much attention has focussed on the conversion of human pluripotent stem cells (PSCs) to a
more naïve developmental status. Here we provide a method for resetting via transient …

Significance: It is increasingly clear that proline metabolism plays an important role in
metabolic reprogramming, not only in cancer but also in related fields such as aging …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

Many cancer cells depend on glutamine as they use the glutaminolysis pathway to generate
building blocks and energy for anabolic purposes. As a result, glutamine transporters are …

The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

The amino acid proline has a unique biological role in stress adaptation. Proline metabolism
is manipulated under stress by multiple and complex regulatory pathways and can …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …