One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates
chromatin organization and either activates or represses gene expression, depending on …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder
characterized by the loss of motor control and cognitive ability, which eventually leads to …

Neuropsychiatric disorders are a collective of cerebral conditions with a multifactorial and
polygenetic etiology. Dysregulation of epigenetic profiles in the brain is considered to play a …

In mammals, RNA interference is primarily a post-transcriptional mechanism. Evidence has
accumulated for additional role in transcriptional gene silencing (TGS) but the question for a …

The histone 3 lysine 9 methyltransferase Setdb1 is essential for both stem cell pluripotency
and terminal differentiation of different cell types. To shed light on the roles of Setdb1 in …

Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine
expansion in the protein huntingtin (HTT)[55]. While the final pathological consequence of …

Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused
by expanded CAG repeats in exon 1 of the Huntingtin (HTT) gene. Altered histone …

The highly repetitive and transcriptionally active ribosomal DNA (rDNA) genes are
exceedingly susceptible to genotoxic stress. Induction of DNA double-strand breaks (DSBs) …

The present study describes evaluation of epigenetic regulation by a small molecule as the
therapeutic potential for treatment of Huntington's disease (HD). We identified 5-allyloxy-2 …