Background Delay in receiving treatment for uncomplicated malaria (UM) is often reported to
increase the risk of developing severe malaria (SM), but access to treatment remains low in …

Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Relationships between viral load, severity of illness, and transmissibility of virus are
fundamental to understanding pathogenesis and devising better therapeutic and prevention …

Cerebral malaria (CM) affects children and adults, but brain swelling is more severe in
children. To investigate features associated with brain swelling in malaria, we performed …

Pathogens are thought to use host molecular cues to control when to initiate life-cycle
transitions, but these signals are mostly unknown, particularly for the parasitic disease …

The action of proteases can be controlled by several mechanisms, including regulation
through gene expression; post-translational modifications, such as glycosylation; zymogen …

Plasmodium replicates within the liver prior to reaching the bloodstream and infecting red
blood cells. Because clinical manifestations of malaria only arise during the blood stage of …

Abstract Purpose of Review Computational and mathematical modeling have become a
critical part of understanding in-host infectious disease dynamics and predicting effective …

The Mediterranean diet (MedDiet) consists of consumption of vegetables and healthy oils
and have beneficial effects on metabolic and inflammatory diseases. Our goal here is to …

Objectives The amount of SARS-CoV-2 detected in the upper respiratory tract (URT viral
load) is a key driver of transmission of infection. Current evidence suggests that mechanisms …