Background Noncompliance with radiotherapy (RT) protocol guidelines has been linked to
inferior clinical outcomes. We performed a meta-analysis of cooperative group trials to …

Medulloblastoma is the most common embryonal tumour in children. Patients with
medulloblastoma are currently staged as average-risk or poor-risk on the basis of clinical …

PURPOSE: Limiting the neurocognitive sequelae of radiotherapy (RT) has been an
objective in the treatment of medulloblastoma. Conformal RT to less than the entire posterior …

Simple Summary The European trial SIOP PNET5 MB was initiated in 2014 and will remain
open to recruitment until 2022. It is the first European trial using clinical, histological, and …

Abstract Purpose Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are
still widely used. Modern techniques (IMRT, VMAT, TomoTherapy®, proton pencil beam …

Medulloblastomas are primary malignant embryonal tumours of the central nervous system.
They are the most common childhood central nervous system tumour, but are rare in the …

Post-operative craniospinal irradiation and systemic chemotherapy are both necessary in
the treatment of pediatric medulloblastoma. Late toxicity is a major problem in long term …

Objective To develop a consensus guideline for craniospinal target volume (TV) delineation
in children and young adults participating in SIOPE studies in the era of high-precision …

Purpose: To assess prognostic factors for adults with medulloblastoma in a multicenter,
retrospective study. Methods and Materials: Data were collected by file review or mail inquiry …

Objective The primary objective of this study was to decrease the late effects of prophylactic
radiation without reducing survival in standard-risk childhood medulloblastoma. Patients …