New discoveries on the biology and detection of human chorionic gonadotropin

LA Cole - Reproductive Biology and Endocrinology, 2009 - Springer
Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprising 2 subunits,
alpha and beta joined non covalently. While similar in structure to luteinizing hormone (LH) …

The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy

SD Barnett, ILO Buxton - Critical reviews in biochemistry and …, 2017 - Taylor & Francis
Abstract S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol
dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that …

Nicotine in senescence and atherosclerosis

AM Centner, PG Bhide, G Salazar - Cells, 2020 - mdpi.com
Cigarette smoke is a known exacerbator of age-related pathologies, such as cardiovascular
disease (CVD), atherosclerosis, and cellular aging (senescence). However, the role of …

Novel identification and modulation of the mechanosensitive Piezo1 channel in human myometrium

SD Barnett, H Asif, ILO Buxton - The Journal of physiology, 2023 - Wiley Online Library
Approximately 10% of US births deliver preterm before 37 weeks of completed gestation.
Premature infants are at risk for life‐long debilitating morbidities and death, and …

The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants

A Berenyiova, M Grman, A Mijuskovic, A Stasko… - Nitric Oxide, 2015 - Elsevier
The chemical interaction of sodium sulfide (Na 2 S) with the NO-donor S-nitrosoglutathione
(GSNO) has been described to generate new reaction products, including polysulfides and …

Regulation of uterine function: a biochemical conundrum in the regulation of smooth muscle relaxation

ILO Buxton - Molecular Pharmacology, 2004 - ASPET
Premature birth accounts for the majority of fetal morbidity and mortality in the developed
world and is disproportionately represented in some populations, such as African Americans …

A role for voltage‐gated, but not Ca2+‐activated, K+ channels in regulating spontaneous contractile activity in myometrium from virgin and pregnant rats

PI Aaronson, U Sarwar, S Gin… - British journal of …, 2006 - Wiley Online Library
The roles of voltage‐gated (KV) and large conductance Ca2+‐activated K+ (BKCa)
channels in regulating basal contractility in myometrial smooth muscle are unresolved. The …

β3 Receptor Signaling in Pregnant Human Myometrium Suggests a Role for β3 Agonists as Tocolytics

ILO Buxton, H Asif, SD Barnett - Biomolecules, 2023 - mdpi.com
Preterm labor leading to preterm birth is the leading cause of infant morbidity and mortality.
At the present time, nothing can reliably halt labor once it begins. The knowledge that …

Matrix metalloproteinases 2 and 9 are elevated in human preterm laboring uterine myometrium and exacerbate uterine contractility

CC Ulrich, V Arinze, CB Wandscheer… - Biology of …, 2019 - academic.oup.com
Abstract Matrix metalloproteinases 2 and 9 (MMP2/9) have previously been shown to be
elevated in serum and amniotic fluid from women undergoing preterm birth. We performed …

Pharmacological techniques for the in vitro study of the uterus

DJ Crankshaw - Journal of pharmacological and toxicological methods, 2001 - Elsevier
During the first decade of the 21st century it is unlikely that the pages of specialist
pharmacology journals will overflow with papers reporting studies on the isolated uterus …