Redox-active quinones and ascorbate: an innovative cancer therapy that exploits the vulnerability of cancer cells to oxidative stress

J Verrax, R Beck, N Dejeans, C Glorieux… - Anti-Cancer Agents …, 2011 - ingentaconnect.com
Cancer cells are particularly vulnerable to treatments impairing redox homeostasis. Reactive
oxygen species (ROS) can indeed play an important role in the initiation and progression of …

Biological activity of quinones

MJA Martínez, PB Benito - Studies in Natural Products Chemistry, 2005 - Elsevier
Quinones constitute a structurally diverse class of phenolic compounds with a wide range of
pharmacologial properties, which are the basis for different applications in the broad field of …

A new synthetic access to furo [3, 2-f] chromene analogues of an antimycobacterial

L Alvey, S Prado, V Huteau, B Saint-Joanis… - Bioorganic & medicinal …, 2008 - Elsevier
From the structure of 3, 3-dimethyl-3H-benzofuro [3, 2-f][1]-benzopyran, a selective in vitro
inhibitor of mycobacterial growth, we have undertaken a structure–activity relationship …

Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity

JA Valderrama, P Colonelli, D Vásquez… - Bioorganic & medicinal …, 2008 - Elsevier
In the search for new potentially anticancer drugs, series of angucyclinone aza-analogues
containing pyridine and pyridopyridazine rings have been designed and synthesized by a …

Intramolecular Hydrogen Bond in Biologically Active o-Carbonyl Hydroquinones

M Martínez-Cifuentes, BE Weiss-López, LS Santos… - Molecules, 2014 - mdpi.com
Intramolecular hydrogen bonds (IHBs) play a central role in the molecular structure,
chemical reactivity and interactions of biologically active molecules. Here, we study the IHBs …

The solar-chemical photo-Friedel–Crafts heteroacylation of 1, 4-quinones

J Benites, D Rios, P Díaz, JA Valderrama - Tetrahedron Letters, 2011 - Elsevier
Photochemical reactions between 1, 4-benzo-and 1, 4-naphthoquinone and several
heteroaromatic carbaldehydes were investigated under solar irradiation conditions. These …

Synthetic strategies to terpene quinones/hydroquinones

M Gordaliza - Marine drugs, 2012 - mdpi.com
The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and-
hydroquinones from sponges offer promising opportunities for the development of new …

Studies on quinones. Part 38: Synthesis and leishmanicidal activity of sesquiterpene 1, 4-quinones

JA Valderrama, J Benites, M Cortés… - Bioorganic & medicinal …, 2003 - Elsevier
The reaction of (+)-euryfuran 1 with several benzo-, naphtho-and benzo [b] thiophene-1, 4-
quinones in acetic acid yields the corresponding euryfuryl-1, 4-quinones 3, 5, 7, 8, 10, 12 …

Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones

JA Valderrama, MF González… - Bioorganic & medicinal …, 2006 - Elsevier
In the search for new potentially anticancer drugs, isoquinolinequinone-containing
polycyclic compounds have been designed and synthesized through highly regiocontrolled …

Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines

J Benites, JA Valderrama, F Rivera, L Rojo… - Bioorganic & medicinal …, 2008 - Elsevier
The preparation of furyl-1, 4-quinone and hydroquinones by reaction of 2-furaldehyde N, N-
dimethylhydrazone with benzo-and naphthoquinones is reported. Access to …