Selected reaction monitoring (SRM) is a targeted mass spectrometry technique that is
emerging in the field of proteomics as a complement to untargeted shotgun methods. SRM is …

In its early years, mass spectrometry (MS)-based proteomics focused on the cataloging of
proteins found in different species or different tissues. By 2005, proteomics was being used …

We have investigated the precision of peptide quantitation by MALDI-TOF mass
spectrometry (MS) using six pairs of proteotypic peptides (light) and same-sequence stable …

Proper genome packaging requires coordination of both DNA and histone metabolism.
While histone gene transcription and RNA processing adequately provide for scheduled …

Recent studies using stable isotope labeling with amino acids in culture (SILAC) in
quantitative proteomics have made mention of the problematic conversion of isotope-coded …

Quantitative targeted proteomics has recently taken front stage in the proteomics community.
Centered on multiple reaction monitoring–mass spectrometry (MRM–MS) methodologies …

Background Many adult tissues contain a population of stem cells with the ability to
regenerate structures similar to the microenvironments from which they are derived in vivo …

Adult stem cells, such as human mesenchymal stem cells (hMSCs), show limited
proliferative capacity and, after long-term culture, lose their differentiation capacity and are …

Stable isotope labeling by amino acids in cell culture (SILAC) is a powerful quantitative
proteomics platform for comprehensive characterization of complex biological systems …

Mass Spectrometry-based proteomics is now considered a relatively established strategy for
protein analysis, ranging from global expression profiling to the identification of protein …