New Insights into the Cooperativity and Dynamics of Dimeric Enzymes

KW Chen, TY Sun, YD Wu - Chemical Reviews, 2023 - ACS Publications
A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …

Enhancement of thermostability and catalytic properties of ammonia lyase through disulfide bond construction and backbone cyclization

ZF Ni, N Li, P Xu, ZW Guo, MH Zong, WY Lou - International Journal of …, 2022 - Elsevier
Ammonia lyases have great application potential in food and pharmaceuticals owing to their
unique ammonia addition reaction and atom economy. A novel methylaspartate ammonia …

Decoding Phospho-Regulation and Flanking Regions in Autophagy-Associated Short Linear Motifs: A Case Study of Optineurin-LC3B Interaction

ON Antonescu, M Utichi, V Sora, M Tiberti, E Maiani… - bioRxiv, 2023 - biorxiv.org
Abstract Short Linear Motifs (SLiMs) play a pivotal role in mediating interactions between
intrinsically disordered proteins and their binding partners. SLiMs exhibit sequence …

Structure-guided protein engineering of ammonia lyase for efficient synthesis of sterically bulky unnatural amino acids

ZF Ni, P Xu, MH Zong, WY Lou - Bioresources and Bioprocessing, 2021 - Springer
Enzymatic asymmetric amination addition is seen as a promising approach for synthesizing
amine derivatives, especially unnatural amino acids, which are valuable precursors to fine …