Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …

Purpose—Our goal is to provide an overview of the current evidence about components of
the evaluation and treatment of adults with acute ischemic stroke. The intended audience is …

Background and Purpose—The authors present an overview of the current evidence and
management recommendations for evaluation and treatment of adults with acute ischemic …

Objective: To determine the effects of antiplatelet therapy among patients at high risk of
occlusive vascular events. Design: Collaborative meta-analyses (systematic overviews) …

Background Thrombolysis for acute ischaemic stroke has been investigated in several
clinical trials, with variable results. We have assessed the safety and efficacy of intravenous …

Objectives This article provides recommendations on the use of antithrombotic therapy in
patients with stroke or transient ischemic attack (TIA). Methods We generated treatment …

Background and Purpose—The National Institutes of Health (NIH) estimates that stroke
costs now exceed $45 billion per year. Stroke is the third leading cause of death and one of …

Background Most strokes are due to blockage of an artery in the brain by a blood clot.
Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage …

Background and Purpose—The Barthel Index (BI) and the Modified Rankin Scale (MRS) are
commonly used scales that measure disability or dependence in activities of daily living in …

Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary
dysfunction, resulting in oedema formation and haemorrhagic conversion. There are …