Excitatory amino acids and Alzheimer's disease
JT Greenamyre, AB Young - Neurobiology of aging, 1989 - Elsevier
Excitatory amino acids (EAA) such as glutamate and aspartate are major transmitters of the
cerebral cortex and hippocampus and EAA mechanisms appear to play a role in learning …
cerebral cortex and hippocampus and EAA mechanisms appear to play a role in learning …
Tacrine: a pharmacological review
SE Freeman, RM Dawson - Progress in neurobiology, 1991 - Elsevier
Tacrine: A pharmacological review - ScienceDirect Skip to main contentSkip to article Elsevier
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[PDF][PDF] Tetrahydroaminoacridine block of N-methyl-D-aspartate-activated cation channels in cultured hippocampal neurons.
N Hershkowitz, MA Rogawski - Molecular pharmacology, 1991 - Citeseer
The action of tetrahydroaminoacridine(THA), a centrally active cholinesterase inhibitor that
may provide symptomatic benefit in Alzheimer's disease, was studied on responses to the …
may provide symptomatic benefit in Alzheimer's disease, was studied on responses to the …
The effect of tacrine (THA) on cycloheximide-and basal forebrain lesion-induced memory deficit in rats
T Nabeshima, E Maruyama, A Katoh… - The Japanese Journal …, 1991 - jstage.jst.go.jp
The effects of 9-amino-1, 2, 3, 4-tetrahydroacridine (tacrine), an active acetylcholinesterase
inhibitor, on cycloheximide and basal forebrain (BF) lesion-in duced memory deficit in the …
inhibitor, on cycloheximide and basal forebrain (BF) lesion-in duced memory deficit in the …
Tetrahydroaminoacridine attenuates dizocilpine-induced behavioural changes
U Keseberg, WJ Schmidt - Behavioural brain research, 1993 - Elsevier
The acetylcholinesterase inhibitor tetrahydroaminoacridine (THA) is known to interact with
neurotransmitter systems other than the cholinergic, eg several studies have shown …
neurotransmitter systems other than the cholinergic, eg several studies have shown …
Effect of 9-amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclopenta-(b)-quinoline monohydrate hydrochloride (NIK-247) on cholinergic enzyme activity in rats
S Shibanoki, Y Ishii, T Kubo, M Kogure, S Asai… - Pharmacology …, 1991 - Elsevier
An in vitro comparison demonstrated that the concentration of NIK-247 that the inhibited
cholinesterase (ChE) activities to half the normal level (ID 50) was 1.3× 10− 6 M. This value …
cholinesterase (ChE) activities to half the normal level (ID 50) was 1.3× 10− 6 M. This value …
Protection by tacrine and some adjuncts against the depressant effects of soman in guinea-pig atrium
WM Lau - General pharmacology, 1993 - apps.dtic.mil
The negative inotropic effects of soman have been reported previously. It was suggested
that the depression in atrial force of contraction was a consequence of continuous …
that the depression in atrial force of contraction was a consequence of continuous …
[图书][B] Cortical neurones in Alzheimer's disease.
JE Steele - 1990 - search.proquest.com
Two major neurotransmitter systems, cholinergic and glutamatergic, have been studied,
mainly in the cortex of patients with Alzheimer's disease. Choline acetyltransferase (ChAT) …
mainly in the cortex of patients with Alzheimer's disease. Choline acetyltransferase (ChAT) …
[图书][B] An animal model evaluation of the therapeutic use of memantine, and memantine and tacrine, for the treatment of Alzheimer's disease
CE Creeley - 2005 - search.proquest.com
Memantine is a new drug recently approved in the US for treatment of moderate to severe
Alzheimer's disease (AD). Clinical evidence has been reported that memantine is …
Alzheimer's disease (AD). Clinical evidence has been reported that memantine is …