Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

▪ Abstract The aim of this review is to provide a basic framework for understanding the
function of mammalian transient receptor potential (TRP) channels, particularly as they have …

Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

The inositol 1, 4, 5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …

The endoplasmic reticulum (ER) is a multifunctional signaling organelle that controls a wide
range of cellular processes such as the entry and release of Ca2+, sterol biosynthesis …

TRP channel proteins constitute a large and diverse family of proteins that are expressed in
many tissues and cell types. This family was designated TRP because of a spontaneously …

Cardiac hypertrophy is a leading predicator of progressive heart disease that often leads to
heart failure and a loss of cardiac contractile performance associated with profound …

Receptor signaling at the plasma membrane often releases calcium from intracellular stores.
For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C …