Osteoarthritis (OA), one of the most common joint diseases, is characterized by fibrosis,
rhagadia, ulcers and attrition of articular cartilage due to a number of factors. The etiology of …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA).
It is now clear that these cytokines play a fundamental role in the processes that cause …

Tumor necrosis factor-α (TNF) has been implicated in the pathogenesis of a variety of
human diseases including septic shock, cachexia, graft-versus-host disease and several …

The aetiology of systemic, autoimmune, chronic inflammatory diseases—such as
rheumatoid arthritis—is not known, and their pathogenesis is complex and multifactorial …

There is considerable evidence implicating tumor necrosis factor alpha (TNF-alpha) in the
pathogenesis of rheumatoid arthritis. This evidence is based not only on the universal …

There is an increasing body of evidence that synovitis plays a role in the progression of
osteoarthritis and that overproduction of cytokines and growth factors from the inflamed …

Using immunoaffinity‐purified polyclonal anti‐human recombinant tumor necrosis factor α
(TNFα) F (ab′) 2 fragments and immunohistochemical techniques, the cells that make …

Tumor necrosis factor-alpha (TNFα) antagonists have shown remarkable efficacy in a variety
of immune-mediated inflammatory diseases (IMIDs). Therapeutic scope and limitations of …