Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

The eukaryotic cell has developed intricate machineries that monitor and maintain proteome
homeostasis in order to ensure cellular functionality. This involves the carefully coordinated …

Copy number variation (CNV) at 7q11. 23 causes Williams-Beuren syndrome (WBS) and 7q
microduplication syndrome (7Dup), neurodevelopmental disorders (NDDs) featuring …

Dopamine (DA) loss in Parkinson's disease (PD) causes debilitating motor deficits.
However, dopamine is also widely linked to reward prediction and learning, and the …

There is a fundamental gap in understanding the consequences of tau–ribosome
interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and they …

Abstract Phosphorylation of Ribosomal Protein S6 (RPS6) was the first post-translational
modification of the ribosome to be identified and is a commonly-used readout for mTORC1 …

Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological
disorders that share common clinical features, such as language impairment, executive …

We previously reported that astrocyte-derived proinflammatory cytokine interleukin (IL)-17A
could aggravate neuronal ischemic injuries and strength autophagy both in oxygen-glucose …

Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with
atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms …

Kappa opioid receptor (KOR) agonists produce analgesic and anti-pruritic effects, but their
clinical application was limited by dysphoria and hallucinations. Nalfurafine, a clinically used …