Changing of the guard: How the Lyme disease spirochete subverts the host immune response

G Chaconas, M Castellanos, TB Verhey - Journal of Biological Chemistry, 2020 - ASBMB
Lyme disease, also known as Lyme borreliosis, is the most common tick-transmitted disease
in the Northern Hemisphere. The disease is caused by the bacterial spirochete Borrelia …

Structure, Function, and Evolution of Linear Replicons in Borrelia

G Chaconas, K Kobryn - Annual review of microbiology, 2010 - annualreviews.org
Spirochetes of the genus Borrelia include important human pathogens that cause Lyme
borreliosis and relapsing fever. The genomes of Borrelia species can be composed of up to …

Genome Stability of Lyme Disease Spirochetes: Comparative Genomics of Borrelia burgdorferi Plasmids

SR Casjens, EF Mongodin, WG Qiu, BJ Luft… - PloS one, 2012 - journals.plos.org
Lyme disease is the most common tick-borne human illness in North America. In order to
understand the molecular pathogenesis, natural diversity, population structure and epizootic …

Whole-Genome Sequences of Thirteen Isolates of Borrelia burgdorferi

SE Schutzer, CM Fraser-Liggett, SR Casjens… - Journal of …, 2011 - Am Soc Microbiol
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The
first complete genome sequence of B. burgdorferi strain 31, available for more than a …

Plasmid diversity and phylogenetic consistency in the Lyme disease agent Borrelia burgdorferi

SR Casjens, EB Gilcrease, M Vujadinovic… - BMC genomics, 2017 - Springer
Background Bacteria from the genus Borrelia are known to harbor numerous linear and
circular plasmids. We report here a comparative analysis of the nucleotide sequences of 236 …

Primordial origin and diversification of plasmids in Lyme disease agent bacteria

SR Casjens, L Di, S Akther, EF Mongodin, BJ Luft… - BMC genomics, 2018 - Springer
Background With approximately one-third of their genomes consisting of linear and circular
plasmids, the Lyme disease agent cluster of species has the most complex genomes among …

Whole genome sequencing of Borrelia miyamotoi isolate Izh-4: reference for a complex bacterial genome

KV Kuleshov, G Margos, V Fingerle, J Koetsveld… - BMC genomics, 2020 - Springer
Abstract Background The genus Borrelia comprises spirochaetal bacteria maintained in
natural transmission cycles by tick vectors and vertebrate reservoir hosts. The main groups …

[HTML][HTML] Genomic confirmation of Borrelia garinii, United States

N Rudenko, M Golovchenko, A Horak… - Emerging Infectious …, 2023 - ncbi.nlm.nih.gov
Lyme disease is a multisystem disorder primarily caused by Borrelia burgdorferi sensu lato.
However, B. garinii, which has been identified on islands off the coast of Newfoundland and …

Structure analysis of the telomere resolvase from the Lyme disease spirochete Borrelia garinii reveals functional divergence of its C-terminal domain

C Semper, N Watanabe, E Karimullina… - Nucleic Acids …, 2024 - academic.oup.com
Borrelia spirochetes are the causative agents of Lyme disease and relapsing fever, two of
the most common tick-borne illnesses. A characteristic feature of these spirochetes is their …

Replication and maintenance of linear phage-plasmid N15

NV Ravin - Microbiology Spectrum, 2015 - Am Soc Microbiol
The lambdoid phage N15 of Escherichia coli is very unusual among temperate phages in
that its prophage is not integrated into the chromosome but is a linear plasmid molecule with …