Introduction‐Imaging of hypoxic areas‐Hypoxia markers‐Positron emission tomography
(PET)‐Near‐infrared spectroscopy (NIRS)‐Magnetic resonance spectroscopy (MRS) …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

Resistance of human tumors to anticancer drugs is most often ascribed to gene mutations,
gene amplification, or epigenetic changes that influence the uptake, metabolism, or export of …

During the past century it has been established that regions within solid tumours experience
mild to severe O2 deprivation owing to aberrant vascular function. These hypoxic regions …

The American Society of Clinical Oncology (ASCO) previously published evidencebased
guidelines for the treatment of unresectable non–small-cell lung cancer (NSCLC)[1]. ASCO …

Despite years of research, the five-year survival rate among patients with lung cancer is a
mere 14 percent. Lung cancer is divided into two major types—non–small-cell lung cancer …

Tissue hypoxia occurs where there is an imbalance between oxygen supply and
consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of …