Cellular and Molecular Mechanisms Regulating Retinal Synapse Development
WA Stevens-Sostre, M Hoon - Annual Review of Vision Science, 2024 - annualreviews.org
Synapse formation within the retinal circuit ensures that distinct neuronal types can
communicate efficiently to process visual signals. Synapses thus form the core of the visual …
communicate efficiently to process visual signals. Synapses thus form the core of the visual …
Molecular insights into the activation mechanism of GPR156 in maintaining auditory function
X Ma, LN Chen, M Liao, L Zhang, K Xi, J Guo… - Nature …, 2024 - nature.com
The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large
extracellular region, plays a pivotal role in auditory function through G i2/3. Here, we firstly …
extracellular region, plays a pivotal role in auditory function through G i2/3. Here, we firstly …
Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing
Y Yun, H Jeong, T Laboute, KA Martemyanov… - Nature …, 2024 - nature.com
GPR179, an orphan class C GPCR, is expressed at the dendritic tips of ON-bipolar cells in
the retina. It plays a pivotal role in the initial synaptic transmission of visual signals from …
the retina. It plays a pivotal role in the initial synaptic transmission of visual signals from …
EGFLAM exhibits oncogenic activity and shows promise as a prognostic biomarker and therapeutic target in glioblastoma
K Li, Q Zhu, S Du, Q Zhao, D Ba, X Zeng, Q Peng… - International …, 2024 - Elsevier
Glioblastoma (GBM) remains the most lethal primary brain tumor, characterized by dismal
survival rates. Novel molecular targets are urgently required to enhance therapeutic …
survival rates. Novel molecular targets are urgently required to enhance therapeutic …
Molecular insights into the atypical activation mechanism of GPR156 in maintaining auditory function
X Ma, LN Chen, M Liao, L Zhang, K Xi, J Guo, C Shen… - bioRxiv, 2024 - biorxiv.org
The class C orphan GPCR GPR156, which lacks the typical extracellular region, plays a
pivotal role in auditory function through Gi2/3. Here, we demonstrate that GPR156 with high …
pivotal role in auditory function through Gi2/3. Here, we demonstrate that GPR156 with high …